Publications
- Stem cell therapies for diabetes
- Process Optimization in Autologous Stem Cell–Derived Islet Generation to Address Key Limitations for Scalability, Safety, and Efficacy
- Scale up manufacturing approach for production of human induced pluripotent stem cell-derived islets using Vertical Wheel® bioreactors
- Scalable Bioreactor-based Suspension Approach to Generate Stem Cell–derived Islets From Healthy Donor-derived iPSCs
- AT7867 promotes pancreatic progenitor differentiation of human iPSCs
- Mitochondrial regulation in human pluripotent stem cells during reprogramming and β cell differentiation
- The Current Status of Allogenic Islet Cell Transplantation
- Complete Suspension Differentiation of Human Pluripotent Stem Cells into Pancreatic Islets Using Vertical Wheel® Bioreactors
- Suspension culture improves iPSC expansion and pluripotency phenotype
- Towards Early Prediction of Human iPSC Reprogramming Success
- Cell Characterization, Graft Evaluation, and Yield of Islet-Like Cells Differentiated From Patient-Derived iPSCs
- AT7867 promotes pancreatic progenitor differentiation of human iPSCs and accelerates diabetes reversal
- Stem Cell–Derived Islet Transplantation in Patients With Type 2 Diabetes: Can Diabetes Subtypes Guide Implementation?
- Evaluating the Potential for ABO-incompatible Islet Transplantation: Expression of ABH Antigens on Human Pancreata, Isolated Islets, and Embryonic Stem Cell-derived Islets
- Characterization of stem-cell-derived islets during differentiation and after implantation
- Opportunities and impediments of human pluripotent stem cell-derived islets in the treatment of diabetes
- Optimizing Generation of Stem Cell-Derived Islet Cells
- Current Status, Barriers, and Future Directions for Humanized Mouse Models to Evaluate Stem Cell–Based Islet Cell Transplant
- Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) agonists in islet transplantation: Endogenous in vivo regulatory T cell expansion promotes prolonged allograft survival
- Progress in Translational Regulatory T Cell Therapies for Type 1 Diabetes and Islet Transplantation
- 5-Aza-2′-Deoxycytidine and Valproic Acid in Combination with CHIR99021 and A83-01 Induce Pluripotency Genes Expression in Human Adult Somatic Cells
- Inducible Pluripotent Stem Cells as a Potential Cure for Diabetes
- Pan-caspase inhibitor F573 mitigates liver ischemia reperfusion injury in a murine model
- Posttransplant Characterization of Long-term Functional hESC-Derived Pancreatic Endoderm Grafts
- Improved islet recovery and efficacy through co-culture and co-transplantation of islets with human adipose-derived mesenchymal stem cells
- Bioengineered human pseudoislets form efficiently from donated tissue, compare favourably with native islets in vitro and restore normoglycaemia in mice
- BMX-001, a novel redox-active metalloporphyrin, improves islet function and engraftment in a murine transplant model
- Ferroptosis-inducing agents compromise in vitro human islet viability and function
- Engraftment Site and Effectiveness of the Pan-Caspase Inhibitor F573 to Improve Engraftment in Mouse and Human Islet Transplantation in Mice
- Low energy X-ray (grenz ray) treatment of purified islets prior to allotransplant markedly decreases passenger leukocyte populations
- Transplantation of Human Pancreatic Endoderm Cells Reverses Diabetes Post Transplantation in a Prevascularized Subcutaneous Site
- Long-term function and optimization of mouse and human islet transplantation in the subcutaneous device-less site
- Antiaging Glycopeptide Protects Human Islets Against Tacrolimus-Related Injury and Facilitates Engraftment in Mice
- Reparixin, a CXCR1/2 inhibitor in islet allotransplantation
- A novel redox-active metalloporphyrin reduces reactive oxygen species and inflammatory markers but does not improve marginal mass engraftment in a murine donation after circulatory death islet transplantation model
- Harnessing the Foreign Body Reaction in Marginal Mass Device-less Subcutaneous Islet Transplantation in Mice
- Photoacoustic imaging of angiogenesis in a subcutaneous islet transplant site in a murine model
- Lung-Derived Microscaffolds Facilitate Diabetes Reversal after Mouse and Human Intraperitoneal Islet Transplantation
- The metalloporphyrin BMX-010 in human islet isolation and clinical transplantation
- Subcutaneous clinical islet transplantation in a prevascularized subcutaneous pouch – preliminary experience
- Diabetes Is Reversed in a Murine Model by Marginal Mass Syngeneic Islet Transplantation Using a Subcutaneous Cell Pouch Device
- A prevascularized subcutaneous device-less site for islet and cellular transplantation
- Bioengineered stem cells as an alternative for islet cell transplantation
- The Combination of Anti-NKG2D and CTLA-4 Ig Therapy Prolongs Islet Allograft Survival in a Murine Model
- Human Islet Viability and Function Is Maintained During High-density Shipment in Silicone Rubber Membrane Vessels
- The Combination of Anti-NKG2D and CTLA-4 Ig Therapy Prolongs Islet Allograft Survival in a Murine Model
- Human Islet Viability and Function Is Maintained During High-density Shipment in Silicone Rubber Membrane Vessels
- Glutathione Ethyl Ester Supplementation during Pancreatic Islet Isolation Improves Viability and Transplant Outcomes in a Murine Marginal Islet Mass Model
- Targeting Cells Causing Split Tolerance Allows Fully Allogeneic Islet Survival With Minimal Conditioning in NOD Mixed Chimeras
- Caspase Inhibitor IDN6556 Facilitates Marginal Mass Islet Engraftment in a Porcine Islet Autotransplant Model
- Anakinra Potentiates the Protective Effects of Etanercept in Transplantation of Marginal Mass Human Islets in Immunodeficient Mice
- AEB071 (sotrastaurin) does not exhibit toxic effects on human islets in vitro nor after transplantation into immunodeficient mice
- Resveratrol fails to improve marginal mass engraftment of transplanted islets of Langerhans in mice
- The caspase inhibitor IDN-6556 (PF3491390) improves marginal mass engraftment after islet transplantation in mice
- Histopaque provides optimal mouse islet purification kinetics: Comparison study with Ficoll, iodixanol and dextran
- Detecting Rejection after Mouse Islet Transplantation Utilizing Islet Protein-Stimulated ELISPOT
- The Use of Bovine Pericardial Buttress on Linear Stapler Fails to Reduce Pancreatic Fistula Incidence in a Porcine Pancreatic Transection Model
- Comparison of Human Islet Isolation Outcomes Using a New Mammalian Tissue-Free Enzyme Versus Collagenase NB-1
- Caspase Inhibitor Therapy Synergizes With Costimulation Blockade to Promote Indefinite Islet Allograft Survival
- Liraglutide, a long-acting human glucagon-like peptide 1 analogue, improves human islet survival in culture
- Nonsimultaneous Administration of Pancreas Dissociation Enzymes During Islet Isolation
- Porcine Marginal Mass Islet Autografts Resist Metabolic Failure Over Time and Are Enhanced by Early Treatment with Liraglutide
- Effect of different induction strategies on effector, regulatory and memory lymphocyte sub-populations in clinical islet transplantation
- Protein Kinase C Inhibitor, AEB-071, Acts Complementarily With Cyclosporine to Prevent Islet Rejection in Rats
- The Use of an Approved Biodegradable Polymer Scaffold as a Solid Support System for Improvement of Islet Engraftment
- The Caspase Selective Inhibitor EP1013 Augments Human Islet Graft Function and Longevity in Marginal Mass Islet Transplantation in Mice
- Costimulation Blockade of Both Inducible Costimulator and CD40 Ligand Induces Dominant Tolerance to Islet Allografts and Prevents Spontaneous Autoimmune Diabetes in the NOD Mouse
- Robust Tolerance to Fully Allogeneic Islet Transplants Achieved by Chimerism with Minimal Conditioning
- Multiple Combination Therapies Involving Blockade of ICOS/B7RP-1 Costimulation Facilitate Long-Term Islet Allograft Survival
- Protective effects of cyclosporine and its analog NIM-811 in a murine model of hepatic ischemia-reperfusion injury
- Preclinical models of acute liver failure: a comprehensive review
- Progress in Translational Regulatory T Cell Therapies for Type 1 Diabetes and Islet Transplantation
- Stem Cell–Derived Islet Transplantation in Patients With Type 2 Diabetes: Can Diabetes Subtypes Guide Implementation?
- Machine Perfusion of the Liver: Applications Beyond Transplantation